Cystitis: where to start?

Here are some notions that will allow you to know and understand certain essential basic concepts to take care of your urological and/or gynecological disorders in a natural, effective and sustainable way.

On this page, we have selected for you a series of information divided into 6 different sections that must be read carefully in order to join our Facebook groups where you can ask questions and find the necessary support and mutual help to fight and solve your problem.

Cystitis: where to start

Cystitis: where to start

Cystitis is not always a urinary tract infection.

It is essential to distinguish:

bacterial cystitis: situation in which the symptoms are directly related to the presence in the urinary tract of uropathogenic germs in large quantities (= urinary infection)

abacterial cystitis: problem in which the symptoms are identical, but urine tests do not show a bacterial presence

The only reliable test to make this distinction is urinalysis. Urine test strips are not enough to identify the presence of bacteria.

Depending on the nature of the cystitis (bacterial or abacterial), the preventive measures to be taken to combat acute episodes and prevent their recurrence will therefore be different depending on whether they are focused: exclusively on the bacterial presence or on a strong inflammation (or both in some cases).

D-Mannose, a natural active ingredient effective against bacterial cystitis

D-Mannose is a natural sugar (usually extracted from birch) not assimilated by the body. This particularity gives it two properties:

1. its impact on blood sugar is low (null below 0.2g/d/kg of weight), which allows it to be taken by anyone in every moment of life;

2. its elimination is done through the urinary system.

This last point is fundamental since it is precisely in the urinary tract that D-Mannose will exert a beneficial action mainly in two ways:

-> inhibition of the adhesion capacity of pathogenic bacteria

The pathogenic germs involved in urinary tract infections (particularly E. coli) are bacteria with fimbriae, that is to say, these bacteria have adhesins: small filaments with a harpoon to adhere to the urothelium (mucous membrane found inside the bladder). and to the urethra. Once firmly established in the bladder wall, bacteria can multiply, causing increasingly strong irritation of the bladder and urethral walls. This inflammation is the cause of the painful symptoms of cystitis.

D-Mannose will form a stronger bacteria/D-Mannose bond than the bacteria/urothelium bond. In such a way:

– D-Mannose binds to “available” bacteria to prevent their adhesion to the bladder wall

-pathogenic bacteria already attached to the mucosa will separate from it to “join” the D-Mannose

The pathogenic germs bound to the D-Mannose will be expelled from the bladder in a simple and natural way with the urinary flow.

-> restoration of the integrity of the bladder and urethral mucous membranes

D-Mannose is produced naturally by our body and is part of the composition of the upper layer of the urothelium: GAGs (Glycosaminoglycans). The main function of this layer of GAGs is the protection of the mucous membrane against irritation.

When cystitis becomes chronic, the inflammation of the urothelium does not have time to fully recover between two acute episodes due to an alteration/destruction of the GAGs layer. This situation increases susceptibility to urinary tract infections and leads to earlier and longer painful symptoms.

D-Mannose will bind to the GAGs layer of the urothelium which will allow a better restoration of its integrity.

Biofilms: first responsible for recurrent cystitis

Bacterial biofilms correspond to a defensive strategy implemented by pathogenic bacteria so that they are not reached by the natural immune defenses of our body or by antibiotics.

Biofilm can be created from the first urinary tract infection.

It is a polysaccharide matrix made by bacteria (of the same species or of several cooperative species).

The mature biofilm regularly expels pathogenic bacteria into the bladder, causing a new cystitis. In this way, it seems that the cystitis is recurrent when, in fact, it is the same infection.

Under these conditions, no treatment is capable of reaching the bacteria enclosed in biofilms. For example, an antibiotic only kills bacteria released in the bladder, but not those contained in them. That’s why cystitis comes back every time we stop therapy.

To overcome this problem, we must act against biofilms.

Cystitis is a multifactorial problem

Cystitis is a multifactorial pathology that tends to be recurrent for various reasons. The causes at the origin of cystitis are variable and differ from one subject to another.

Therefore, it is essential, for an effective and long-lasting fight against recurrent cystitis, to identify the precipitating and predisposing factors in order to intervene globally.

In fact, only a personalized strategy that supports all the risk factors that can lead to the acute episode will effectively and lastingly prevent recurrences.

It is also important to specify that if the presence of pathogenic biofilms is often the predisposing and maintenance factor for cystitis, it is almost never the only cause and is usually associated with other predisposing and/or precipitating factors.

Among the most frequent we can mention:

– transit disorders: constipation and/or diarrhea

– hormonal variations: menstruation, pre-menopause, menopause, pregnancy, postpartum, contraception, etc.

sexual intercourse

antibiotics

– presence of vaginal dysbiosis: altered Döderlein flora, mycosis, vaginosis

– use of hygienic pads/tampons

sea, swimming pool, sauna, etc.

– significant irritation of the mucous membrane (abacterial cystitis)

insufficient water intake

incomplete emptying of the bladder

excessive hygiene

cold/seasonality

– practice of certain sports

Abacterial (inflammatory) cystitis is more common than we think.

Abacterial cystitis or urothelial inflammation is a phenomenon that results from irritation of the bladder mucosa after recurrent acute episodes, repeated use of antibiotics, presence of biofilms (proinflammatory by nature), acid urine, etc. It is an inflammation of the urothelium and gives rise to painful symptoms similar to those of bacterial cystitis but without the presence of germs in the urine (negative urine test).

In a case like this, antibiotic therapy is useless and it is advisable to support the re-epithelialization of the bladder wall from its protective layer (GAGs) to promote the restoration of its integrity and fight against its inflammation.

Certain measures allow, in parallel, to minimize the aggressions suffered by the urothelium and act favorably to reduce inflammation:

– a tendentially alkaline diet limiting: cheese and dairy products, meat and fish and favoring fruit, vegetables, cereals, etc.

– an elimination of oxidizing agents such as alcohol and tobacco

– correct hydration: approximately 1.5 liters of water per day

– use of loose clothing and cotton underwear

– daily intake of a natural anti-inflammatory such as Morinda Citrifolia contained in Ausilium products

Vaginitis, mycosis and vaginosis are 3 different situations

Intimate itching, burning… it is not always about a mycosis!

The only way to understand the origin of the problem is by making a vaginal swab to find out if it is:

-> vaginitis: inflammation of the vulvo-vaginal mucosa without infection

-> mycosis: fungal vaginal infection (often Candida albicans)

-> vaginosis: bacterial vaginal infection (often Gardnerella)

This distinction between inflammation or infection is essential to address the problem and obtain a quick and lasting benefit.

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