Recurrent cystitis and biofilms

A group of bacteria (all of the same species or different species sometimes associated with yeasts and other microorganisms) makes bacterial biofilms. They “weave” a “protective layer” around them and then lock themselves inside it.

In this way, they settle permanently in the bladder because inside this “shell” they cannot be attacked by our natural defenses or by antibiotics. They interact with the external environment and “learn” what our defenses are, they mutate and become increasingly resistant.

This is the reason why taking antibiotics chronically is strongly discouraged, especially in case of recurrent cystitis.

This practice only reinforces the antibiotic resistance of the “persistent cells” = “mother” bacteria found inside the biofilms. The latter can remain silent for long periods, thus giving the impression of a total recovery and then “wake up” at the right time (low immune defenses, intercourse, etc.) to “attack again”.

In the presence of bacterial biofilms, the “typical course” generally looks like this:

– urinary tract infection with positive urine culture test => antibiotic treatment => “cure”

– vaginal mycosis and/or digestive disorders due to the antibiotic (as a broad-spectrum antibiotic is generally used) + symptoms of cystitis with negative urine culture test

=> no management for cystitis and “spontaneous remission”/ vaginal ovules, intimate gel, etc. for mycoses + probiotics for the intestinal flora (and a fiber-free diet for a few days)

– urinary reinfection with positive urine culture test (sometimes the bacteria is the same but if the biofilm is polymicrobial it may be another)

We will overlook all the side effects of this vicious cycle + decreased libido, pain, etc. here.

To get out of this “hellish” spiral, we need to take a radically different approach to the problem: we need to disintegrate the biofilms and fight bacteria while protecting the flora and helping it to restore itself so that our own natural defenses can be effective.

To do that we should:

– use a substance capable of “melting” biofilms: N-acetylcysteine (NAC).

– associate it with D-Mannose which will take care of the bacteria released during the disintegration of the biofilm (D-Mannose binds to the bacteria that therefore become vulnerable and eliminates them from the bladder naturally with urination)

Given the different messages we get about biofilm disruption, we add a very important WARNING:

NAC is found in a lot of products (sold without a prescription) such as medical devices that “melt” nasal and bronchial secretions in case of cough or stuffy nose. Of course, in case of cystitis, a bladder-directed product such as Ausilium NAC should be used and not others for other disorders. Otherwise, we risk a disintegration of the biofilm that is too brutal and without enough D-Mannose to “manage” the bacteria release => acute crisis and pain might be guaranteed. With Ausilium NAC, on the other hand, the doses are created to give to the D-Mannose the time to do its job of “cleaning” and eliminating all pathogenic bacteria.

Also, D-Mannose is one of the normal constituents of the bladder walls, so it will help with its “rebuilding” without side effects (unlike antibiotics).

Regarding the intestinal and vaginal flora, the use of probiotics (several strains of Lactobacilli and Bifidobacterium) associated with prebiotics (Fructooligosaccharides) is a good clue. Personally, we recommend Deaflor, but here we have many more options on the market.

Knowing that by “chronic cystitis” we mean more than 4 episodes per year and that it is estimated that more than 60% of bacterial infections involve bacterial biofilms, we hope that this brief explanation can help you.

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