Mycosis and D-Mannose: a great match?

Today I will reply to a super logical question posed by one of the girls in the forum:

“I need your help! D-Mannose is a sugar and fungi and yeasts love sugar. So, can D-Mannose intake cause or aggravate mycosis?”

To begin, I am very grateful for all this trust and I feel in charge of a good explanatory mission (especially because beyond cystitis, vaginal mycosis has been my second friend due to the amount of antibiotics taken).

“Fungi and yeasts love sugar”: this statement is not entirely accurate.

I used to believe that reducing simple sugars (basically everything I liked) would allow me to limit the growth of Candida albicans (because we mostly talk about it in case of mycosis).

I made multiple attempts at diets (some even extravagant) and that always ended with failure and great frustration. I especially tried to combine that with a reduction in urinary acidifiers to protect my bladder. In short, a true bazaar to drive, now everything seems “easy” if I look back!

One day the dietitian of the gastroenterology department told me: “You don’t know anything about all this because it’s not proven either.” What? This phrase turned me into a bomb and I started looking for reliable scientific evidence that Candida albicans, responsible for my unpleasant losses and intolerable itching, was really stimulated by sugars.

So here are my conclusions:

– Candida albicans is a commensal yeast of the vaginal and intestinal flora. Its presence is perfectly normal and physiological and it is unthinkable to find a balance without it

– Candida albicans has a glucodependent metabolism => it lives well thanks to glucose (so not all sugars, precisely glucose!), but it can also use other nutritional sources for its development: lipids, for example. In this case, according to the conclusion of a study on the subject, the foundations for the formation of a biofilm start

– Candida albicans seems to be able to transform other mono and disaccharides (fructose and sucrose) into glucose to nourish

D-Mannose is not metabolizable => it cannot be converted into glucose and circulates in our blood in its original intact form

– Candida albicans particularly loves iron (that is why people who have systemic candidiasis are often anemic)

– when Candida albicans is in an organ that is not in direct contact with the food bolus (not in the digestive tract in summary), it extracts its nutrients almost exclusively from the blood and, modestly, from the deep tissues of the organ where it is located

– Candida albicans is an aggressive opportunist and will take every opportunity to develop excessively and cause problems in our ecosystem (microbiota)

“The opportunity makes a thief.” That is to say that Candida albicans does not suddenly “decide” to proliferate excessively; it does it only because it has the opportunity to do so and that is what suddenly converts it into a pathogenic.

If we apply this scientific knowledge to our vaginal candidiasis, this is my opinion:

1- vaginal mycosis is not conditioned by the consumption of sugars in the diet

The consumption of simple sugars (fructose and sucrose) and very refined ones (starch) cannot affect its appearance.

So why does Candida appear?

In my case, it was clear that antibiotics had eliminated vaginal lactobacilli and that is why Candida albicans could expand as it wanted.

2- “sweet” foods cause few changes in blood sugar

If it is true that Candida albicans vaginal draws its glucose from the blood, it must also be said that the blood glucose of a healthy person (without diabetes) is constant despite food intake (we have a pancreas).

In this way, the theory of eating a sugar-free diet to fight Candida albicans collapses!

Well, if blood glucose is stable regardless of what we eat, then Candida albicans always has the same amount of nutrition. There is no need to deprive ourselves!

We can add to this, a report from the American College of Dietitians and Nutritionists that has compiled more than 30 studies on anti-candida diets that concludes that there is no relationship between the reduction in sugar consumption and the regression of the proliferation of Candida albicans.

I can’t tell you my reaction when I found this source!

3- D-Mannose cannot be a nutrient of Candida albicans

In fact, it cannot be transformed into glucose, there is no way to modify it to be “consumable”

4- the best method to combat vaginal candidiasis lies in two points:

– Lactobacilli re-establishment to “occupy space” and contain the conquering impulse of Candida albicans

– deprive Candida albicans of the nutrient thanks to which it can really act = iron!

I invite you to read this article not to talk too much about the “anti-mycosis action” part, I think it’s already well explained here

Moral of the story: there is no relationship between D-Mannose and mycosis.

I even think it could be a virtuous circle in reverse: D-Mannose => no cystitis => there is no need for antibiotics => recolonization of the vaginal Lactobacilli => regression of Candida albicans => rebalancing of the physiological flora => reduction of the risk factors of cystitis => there is no need to take antibiotics, etc.

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