D-Mannose resistance: myth or reality?

D-Mannose resistance: one of the most recurrent topic on the web

“Have you heard about D-Mannose resistance? It seems that some E. coli fimbriae are Mannose resistant. Apparently, there are 2 categories of fimbriae: resistant and sensitive ones”.

We should start establishing what fimbriae are: a sort of small eyelashes that cover pathogenic bacteria involved in urinary tract infections.

Each fimbria (also called lectin or adhesin according to the scientific literature) acts as a “mini-harpoon”, allowing the pathogen to anchor firmly to the surface of the bladder mucosa to grow slowly (multiplying and colonizing). Each pathogenic bacterium has dozens (or even hundreds) fimbriae to ensure adherence to the bladder mucosa.

If bacteria don’t adhere to the bladder wall, they remain floating in the urine and will be eliminated with it.

D-Mannose has an adapted “form” to these small fimbriae. Basically, it will stick to them “imitating” the bladder wall. In this way, pathogenic bacteria will “believe” to have adhered to the bladder wall when in fact, they are still “suspended” in the urine. They will simply be eliminated naturally with urination and without side effects (this is the “genius” of this molecule).

This is the trick of D-Mannose: to saturate pathogenic bacteria by sticking to all their fimbriae and prevent the adhesion to the bladder wall (bacteria “linked” to D-Mannose will “float” in the bladder and will be eliminated with urine flow).

This process, beyond being effective, is much more natural and painless than antibiotics intake.

What we do not usually take into account is that antibiotics, by killing pathogenic bacteria, actually make them literally “explode”. This “explosion” (called “lysis” in medicine) causes a significant release of toxins that strongly attack the bladder mucosa and cause inflammatory pain. This enhancement of inflammation is often responsible for residual pain beyond the infectious episode (bladder heaviness, urinary urgency and urethral tingling that lasts several days).

With D-Mannose this would not happen since bacteria would “come out” entire and alive from the bladder.

Well, isn’t it perfect? Well, no. E.coli is a very intelligent bacterium that adapts and mutates. This is one of the reasons why many people doubt D-Mannose.

Well, I’m going to give you at least four supporting elements in favor of D-Mannose:

N ° 1

Studies emphasize that, within the same sample of pathogenic bacteria, not all have “not sensitive to Mannose” fimbriae. In case some have “not sensitive” fimbriae, they never represent the majority.

As a result, D-Mannose will continue to be effective in more than 50% of pathogenic bacteria involved in the current urinary infection which is sufficient to achieve a significant decrease of the bacterial load without the use of antibiotics.

In addition, another study has confirmed this in patients with chronic infections of the urinary tract with Proteus mirabilis with “not sensitive to Mannose” fimbriae.

It must be stressed (because I imagine that some will think that a decrease is not an eradication) that it is completely possible to get rid of pathogenic bacteria only with D-Mannose.

The key is to know the proper dose and maintain a prolonged and constant intake.

N ° 2

It is understood that all pathogenic bacteria do not necessarily have  “not sensitive to Mannose” fimbriae. These studies specify that in some samples there were none! Also, as we said before, even if it were like that, it would not be the majority of cases.

N ° 3

We must not forget that we are not alone in this fight against infections. Our body, even when weakened by antibiotic therapies, is still able to defend itself (I am not referring here to extreme situations of immunocompromised people) with the production of leukocytes.

We can consider that if D-Mannose “manages” the 80% of  “Mannose-sensitive” fimbriae, our immune system will be able to “manage” the other 30% “not sensitive to it”.

I am firmly convinced that Morinda citrifolia present in Ausilium products in association with D-Mannose, makes a great difference since it is an immunostimulant. As a result, these products become even more relevant in the hypothesis of the existence of “not sensitive to Mannose” fimbriae.

Another very important element is that all the studies that showed “no sensitive to D-Mannose” fimbriae are in vitro. This means that they reflect the reality of a urinary infection with its other components: the reaction of the immune system, for example.

No. 4

Not all pathogenic bacteria adhere to the bladder mucosa. They can also stick to each other. This is the first step in the formation of the biofilm. This process does not require the implementation of fimbriae: actually we do not even have to “care” about its sensitivity or not to D-Mannose because it is a fight against aggregation.

To fight against this aggregation is not “enough” to take D-mannose. D-Mannose (Ausilium) + N-acetylcysteine + Morinda citrifolia (for example, Ausilium NAC) will be needed.

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