Cystitis and antibiotics

Very often antibiotic prophylaxis is a dangerous and counterproductive therapeutic approach especially for the most sensitive people.

Here are some important considerations about the side effects of a prolonged antibiotic therapy that are not intended to replace doctor’s advice.

Antibiotic works like a disguise for the infection and keep pathogenic bacteria number low

After an antibiotic intake, the urine culture test will give a negative result. Antibiotic, in fact, indiscriminately kills all sensitive bacteria. In case of recurrent cystitis, if the number of bacteria is 10 million per ml for example, antibiotic intake will reduce this number without achieving bacteria eradication. Paradoxically, even a single bacterium present in the bladder could replicate and cause the onset of cystitis even after 12/24 h.

Especially in case of recurrent cystitis, antibiotic intake may be a temporary solution after which, the urinary infection will probably emerge stronger than before.

Antibiotic has side effects on bladder and urethra mucosa.

By killing bacteria, the antibiotic help them to release toxins with an irritant effect on the mucous membranes. If the urothelium is already damaged by repeated bacterial infections, the antibiotic action, stimulating the release of toxins contained and produced by bacteria, could increase the inflammation of the bladder wall and the persistence of pain, favouring the adhesion of bacteria to the deeper layers of the mucosa.

Antibiotic destroys the physiological flora.

Antibiotic, especially if not carefully selected and with broad spectrum action, can be a real “pump” that systematically kills almost all bacteria that are sensitive to it. The few survivors could become resistant.

This leads to side effects such as:

intestinal dysbiosis

transit disorders (diarrhea, bloating, constipation, nausea)

severe decrease in the body’s general immune defenses

difficulty to fight digestive fungal infection like candidiasis

vaginal dysbiosis

risk of vaginal mycosis

risk of vaginal infection (Gardnerella)

vaginal inflammation (vaginitis)

vaginal dryness that can make intercourse painful (dyspareunia)

Prolonged antibiotics intake promotes resistance.

Antibiotic kills sensitive bacteria. If a single bacterium mutate becoming resistant to that specific antibiotic then it could survive and, if that body part is not in physiological balance, it will multiply to give rise to a new colony of resistant bacteria (a “natural selection” will act favouring the strongest bacterial strains).

Antibiotic is totally ineffective against biofilms.

Biofilms are complex structures of polysaccharides produced by bacteria (a real defense shield). In this way, they can survive in the bladder undisturbed. Biofilms, in fact, behave like a “bacterial deposit” and punctually release bacteria in the bladder. In this way, we will think of a recurrent cystitis when in reality, it is the same recurrent infection.

Biofilms are responsible for the 60-80% of infectious diseases. This percentage increases in case of diseases such as cystitis.

The period of time between two possible reinfections with bacterial cells release is variable (from a few hours to several months). It has not been established if there are external factors that may affect it, but clinical experiences show us that it often coincides with periods of special sensitivity (stress, cold, illness, surgery, low immune response, sexual intercourse, etc.).

Pathogenic bacteria inside the biofilms can belong to different species and strains; it can happen that urine cultures give different results each time (adding more confusion about the origin of our infection). Antibiotic is only effective on bacteria that are released by the biofilms, it has no disruptive action against them and does not eliminate the cause of the urinary infection.

Antibioti intake risks and side effects are definitely underestimated.

In addition to the increase of the phenomenon of antibiotic resistance, which is becoming global, there is also a real possibility of organism intoxication. In general, the oral intake of any substance obviously involves a process of metabolization and elimination. Our body has two large organs that ensure this elimination: liver and kidneys. When the waste to be eliminated is produced physiologically and in normal quantities, the organs for this elimination do not face any problem. On the other hand, if the waste produced is not physiological, as in the case of antibiotics, and if they are used in large quantities as in the case of a prolonged intake, then there is a risk of liver or kidney overload.

Considering that antibiotic intoxication often leaves behind the functioning of the organs and the side effects of antibiotics, we can conclude that antibiotic therapy, if it is not specific and not managed correctly, can be considered potentially dangerous.

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