D-Mannose effectiveness depends on the type of bacteria responsible for the infection. Indeed, not all bacterial lectins are sensitive to the action of this sugar.
Type 1 lectins sensitive to D-Mannose are of 2 types:
- high affinity with D-Mannose (M1H) 70% of those found in urine are of type M1H
- low affinity (M1L). 80% of E. coli isolated in the intestine have lectins of type M1L
This shows that E.coli have a high capacity to mutate, transforming from saprophytic bacteria (bacteria that coexist in the human body without creating damage) into a pathogenic bacteria (capable of causing a pathology).
Bacteria that have this type of lectins sensitive to D-Mannose, in addition to E. coli, are: Klebsiella, Shigella and others.
In addition, there are bacteria without lectins.
Logically D-Mannose is not needed to eliminate this type of bacteria: bacteria without lectins are not able to adhere to mast cells (immune cells responsible for the activation of the inflammatory process) and therefore cannot cause inflammation, pain or damage.
It is common that during D-Mannose intake we have turbid, malodorous urine, full of nitrites (sign of bacterial presence) and positive urine cultures without leukocytes (index of inflammation) and therefore, without suffering significant symptoms. This bacteriuria does not need to be managed because it is not only harmless, it also protects us. The presence of these bacteria removes vital space and nutrients from the aggressive ones, preventing them from colonizing the bladder.
There are P-type lectins, insensitive to D-Mannose too.
These bacteria bind to other elements present in the urinary tissue. This type of bacteria usually causes pyelonephritis, probably because they are also insensitive to the defensive action of lgA and Tamm Horsfall proteins.
In short, D-Mannose is effective against Escherichia coli (responsible for 80% of urinary tract infections), Klebsiella, Shigella and Salmonella as they have type 1 lectins.
Ausilium, thanks to the broad-spectrum antibacterial action of Morinda citrifolia is effective for a wider range of pathogens. The women who have used it confirm its effectiveness even in cystitis caused by: Klebsiella, Shigella, Enterococcus, Staphylococcus, Proteus, Streptococcus, Enterobacter and others.