D-Mannose effectiveness depends on the type of bacteria which are responsible for the infection as not all bacterial lectins are sensitive to its action.
Type 1 lectins sensitive to D-Mannose are of 2 types:
- high affinity with D-Mannose (M1H) 70% of those found in urine are of type M1H
- low affinity (M1L). 80% of E. coli isolated in the intestine have lectins of type M1L
This shows that E.coli have a high capacity to mutate, transforming itself from a saprophytic bacteria (bacteria that coexist in the human body without creating damages) into a pathogenic bacteria (capable of causing a pathology).
Bacteria that have this type of sensitive lectins to D-Mannose, in addition to E. coli, are Klebsiella, Enterococcus, Staphylococcus, Proteus, Estreptococcus, Enterobacter, Shigella, Salmonella, Enterobacter cloacea, Serratia marcescens, etc.
In addition, there are also bacteria without lectins.
Logically D-Mannose is not needed to eliminate them as bacteria without lectins are not able to adhere to mast cells (immune cells responsible for the activation of the inflammatory process) and therefore cannot cause inflammation, pain or damages.