I am still very surprised by all the myths, taboos and misunderstandings that exist about chronic cystitis and pathogenic biofilms. For this reason, I would like to share with you some information about bacterial biofilms in case of chronic infections of the lower urinary tract.
Pathogenic biofilms are the main responsible for recurrent cystitis and, incidentally, for the ineffectiveness of antibiotics.
So, why do doctors, urologists, etc. don’t talk about them?
Very often the biofilm is the “knot” of these disorders.
We should imagine it as a scenery of a real war between uropathogenic agents trying to colonize our bladder and our body’s immune defenses trying to fight back.
Uropathogenic germs involved in urinary tract infections (UTIs) are living units. As such, they have certain requirements and a specific objective: the survival of their species.
In order to make this happen, they need a hospitable environment (perfecty adapted to their temperature, their pH, their water content and nutrients) to establish themselves: our bladder.
They love to disturb other living species so our body cannot remain impassive facing an urinary tract infection: our natural immune defenses try to fight against these pathogens involving leukocytes too.
Even though these germs such as E. coli, Proteus, Klebsiella, Enterococcus, Streptococcus, etc. are small, they have an arsenal of real “strategies” of attack and defense.
Among the best attack strategies they have:
– their rapid and almost exponential growth: up to one generation every 45 minutes [1 bacterium at 6 am -> 2 at 6:45 am -> 4 at 7:30 am -> 16 at 8:15 am and so on).
This rapid increase is directly associated with another skill that makes them formidable: their ability to make their DNA evolve from generation to generation (mutation) to become more and more resistant. This peculiarity is used both in attack and in defense against leukocytes and antibiotics.
They also have another weapon. They have pili, small legs that end with lectins, some kind of harpoons to anchor into the urothelium (bladder and/or urethra) to guarantee the bacterium a strong adhesion to the mucosa (each bacterium has hundreds of pili!).
These small units have also great defense strategies. They can protect themselves effectively and permanently against our natural immune defenses as well as against the weapons that modern medicine offers us: antibiotics!
Bacteria can thus build biofilms.
From the first hours after an infection, they join together and form around themselves this protective mucus completely impenetrable to antibodies and antibiotics. Within the biofilms, pathogenic bacteria will continue to live safely with no possibility to eliminate them.
They will remain “silent” for long periods: weeks or even months, giving the impression of being defeated. Then, one day, suddenly, biofilms will “open up” and release pathogenic germs into the bladder, making us think about a new infection.
This mechanism is still little known, but it has been noted that these “surprise attacks” frequently occur during favorable moments for bacteria such as decreased immune defenses, illness, fatigue, particularly acid urine pH, constipation, sexual activity, etc.
These pathogenic cells can cooperate too. In fact, several pathogenic species (bacterial and/or fungal) can form a biofilm together.
These small units are excellent strategists, but fortunately nowadays, we have effective defense techniques.
We must use our knowledge to defend our body adequately and effectively, without destroying or altering our balance and to finally win this war!
Currently, the ideal approach for recurrent cystitis with the presence of pathogenic biofilms is:
-> antibiotics intake reduction (under medical supervision)
-> disgregation of mature biofilms with an associated intake (14 days, renewable if necessary every 4 to 6 weeks) of:
– Ausilium NAC: 1 vial, morning and night, away from meals
– Ausilium 20 PLUS: 1 sachet, in the afternoon, away from meals
-> parallel preventive interventions on the predisposing and precipitating factors of acute cystitis such as:
– Ausilium Forte as daily prophylaxis
– Ausilium Crema vaginal cream with local application before and after sexual intercourse
– Ausilium Lavanda vaginal douching in case of associated dysbiosis, vaginosis or vulvovaginal Candidiasis
– Lenicand in case of excessive proliferation of Candida albicans
This conclusion is a little “Deakos oriented”, but it has the merit of being concrete as it is estimated that more than 60% of bacterial infections are caused by biofilms.